I know I'm late to this party, but I thought I'd share my experience with cut-out / anatomic saddles.
My quick summary is that they're helpful, especially if you're sensitive and/or having issues. They give everyone some pressure relief.
I'm lucky in that my body isn't terribly particular about saddles. It's also been a function of being on teams where the saddle changes from sponsor to sponsor and having to adapt. Nonetheless, I've found every cut-out saddle to be at least a little bit more comfortable for all the right reasons, and they aren't any harder to setup or ride. As far as I can tell, the only problems with cutout saddles are they may be slightly heavier.
As is typical with saddle advice, you should buy from a local shop that will let you test ride some before you commit to buying.